Dealing with cutaneous and renal glomerular vasculopathy in dogs

Dealing with cutaneous and renal glomerular vasculopathy in dogs
by Laura Holm and David Walker
Abstract
Cutaneous and renal glomerular vasculopathy (CRGV) is a disease of dogs, first reported in racing greyhounds in the USA during the 1980s. The disease causes erosive to ulcerative skin lesions, predominantly affecting the limbs, ventrum and oral cavity; however, a proportion of dogs develop more severe systemic abnormalities, including thrombocytopenia, anaemia and acute kidney injury. The disease was first reported in the UK in 2000, in a single pet greyhound. Since 2012, over 160 cases of CRGV have been confirmed in a wide range of dog breeds; no age or bodyweight predilection has been identified. To date, the cause of CRGV in dogs remains unknown. This article provides a review of the history and clinical signs and advises practitioners on the current approaches to dealing with the condition.

http://dx.doi.org/10.1136/inp.k4368

The articles includes:

  • History of the disease in domestic
    animals
  • Pathogenesis
  • Thrombotic microangiopathies in people
  • Current knowledge of CRGV in the UK
    • Clinical signs
    • Aetiology
    • Investigating suspected cases
    • Approach to cases without apparent
      Acute Kidney Injury (AKI)
    • Approach to cases developing AKI

References

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