About Alabama Rot / CRGV

If your dog gets skin lesions or other symptoms consult your vet, without delay. “Unexplained redness, sores or swelling of the skin (on the paws, legs, body, face, tongue or mouth) are often the first sign of this disease.” (AMVS, Feb 2016)  After five years, we still don’t know what causes Alabama Rot.  From analysis by AlabamaRot.co.uk, we do know that 90% of confirmed cases have been in the six months during Winter and Spring (December – May). Information about Alabama Rot / CRGV for dog owners from Anderson Moores Veterinary Specialists (AMVS).

Continue reading “About Alabama Rot / CRGV”

MP writes to DEFRA minister about Alabama Rot

On 12th June 2018, Victoria Prentis MP (Conservative, Banbury) wrote:

“To ask the Secretary of State for Environment, Food and Rural Affairs, whether his Department is carrying out research to evaluate the cause of and potential threats posed by Alabama Rot to dogs in the UK; and if he will make a statement.”

George Eustice The Minister of State, Department for Environment, Food and Rural Affairs (DEFRA) replied on 20th June:

“A private veterinary group is coordinating an investigation into the cause of the syndrome known as cutaneous and renal glomerular vasculopathy (CRGV) in the UK, which is sometimes referred to as Alabama rot. The Animal and Plant Health Agency has been engaging with this investigation since the outset and continues to do so.”

Source: Hansard HC Deb, 20 June 2018, cW

 

I assume the private veterinary group is Anderson Moores.

Ten more cases of Alabama Rot

Anderson Moores report yesterday:

“Unfortunately, we have to confirm a further ten cases of cutaneous and renal glomerular vasculopathy (often termed CRGV or Alabama Rot). The cases were from Chippenham (Wiltshire), Taunton (Somerset), Westhoughton (G.Manchester), Chulmleigh (Devon), Lydney (Gloucestershire), Tonypandy (Rhondda Cynon Taf), Longhope (Gloucestershire), Salford (G.Manchester), South Molton (Devon) and Brecon (Powys).”

This brings the total number of confirmed cases to 132 since 2012, with 12 cases in 2018. We continue to advise owners to be vigilant and to seek advice from their local vet if their dog develops unexplained skin lesions/sores.

For help recognising some of the signs and to see a map of confirmed cases please visit www.vets4pets.com/stop-alabama-rot/”

Aeromonas hydrophila bacteria not ruled out as Alabama Rot cause

AlabamaRot.co.uk has covered reports about Aeromonas hydrophila here, here and here. Vet Fiona Macdonald hypotheis is that Aeromonas hydrophila bacteria may be a factor in triggering Alabama Rot when conditions are rainy and cold.

The Vet Times report:

Specialist vet studies bacteria cause of Alabama rot Vet Fiona Macdonald is researching whether Aeromonas hydrophila is a link to identifying cause of deadly canine disease. A specialist fish vet is investigating an organism described as “a possible stepping stone” to identifying the cause of one of the UK’s most baffling and lethal canine diseases.

Fish vet Fiona Macdonald is researching whether Aeromonas hydrophila, a heterotrophic, Gram-negative, rod-shaped bacterium, present in water sources and soil, might be involved in the aetiology of CRGV.

In a document sent to Veterinary Times entitled “CRGV (Alabama rot) – an organism of interest?”, Dr Macdonald explained: “There is a suspicion initial cases of CRGV occurred in areas with substantial amounts of water as a result of unusually high rainfall; both running and standing water was close to 4°C for some weeks around the time of the cases.

“To date, dogs appear to be the only species affected, with no reported cases in wild ponies, foxes, cattle or deer. There have been recorded cases of infection with A hydrophila in dogs, which mirrored Leptospira infections, and this pathogen has been on the list of possible causes of CRGV since early manifestations of the problem.”

Dr Macdonald is receiving funding for her work from the New Forest Dog Owners Group, and is appealing for help from UK vets.

She said: “I want blood samples from suspected CRGV cases and I’m happy to send out swabs along with a sampling protocol to any vet for them to swab any suspicious lesions. Email me at fiona@fish-treatment.co.uk”

David Walker, from Anderson Moores Veterinary Specialists, and the UK’s leading authority on CRGV, said: “It’s a nice piece of work… I’m hoping she publishes because it’s a possible stepping stone for either her, or others, to take on the work and truly include or exclude this organism in the Alabama rot investigation.””

The International Animal Health Journal (1) said:

“A bacterium that causes ulcerative skin lesions and kidney failure in fish could be linked to cases of Alabama rot in UK dogs, current research suggests.

Fish vet Dr Fiona Macdonald is co-ordinating a study into whetherAeromonas hydrophila could be a possible cause of cutaneous and renal glomerular vasculopathy (CRGV), also known as Alabama rot.”

The cause is not known yet…

“While the cause is not yet known, it appears to have a seasonal aspect, with most cases occurring between November and June. Initial cases occurred in areas with substantial amounts of water, as a result of unusually high rainfall, during cold weather. Both running water and standing water were 4ºC for some weeks at the time of the cases.”

Does A hydrophila grow in skin lesions causing Alabama Rot?

“A hydrophila was first recorded in dogs in 1995. It is known to cause ulcerative skin lesions in both ornamental and farmed fish, with subsequent kidney failure. The UK strains prefer cold, which could be why it grows in the skin lesions – as they are cooler than the rest of the body.”

A test for A hydrophila antibodies

“Diagnostic laboratory BioBest, in Edinburgh, developed a specific test for A hydrophila antibodies in serum. Dr Macdonald says a significant number of blood samples submitted from suspected CRGV cases, strongly indicated an immune response to the organism. The samples came from dogs living in rural areas across the UK, from southern Scotland to Devon.”

But the evidence for A hydrophila is weak with only one case

“Specialist transport medium swabs have also been sourced to sample skin lesions on first presentation to a veterinary surgeon. These are subjected to specific culture conditions for Aeromonads. So far, Dr Macdonald says there has been only one positive isolation of the organism from a swab taken from a suspect lesion. This dog also produced a positive antibody response to the organism.”

Research thus far has also involved testing canine kidney cells in tissue culture to determine if there are any effects associated with the A hydrophila. Dr Macdonald says the theory is that toxins from the organisms cause kidney problems in affected dogs, rather than direct infection by the organism itself. This could explain why the organism has never been isolated so far in affected dog kidneys.

Results show that both the medium in which the organism has been grown, and the inactivated organism, killed the dog kidney cells in tissue culture – even after significant dilution. Dr Macdonald says this goes a long way to confirming the involvement of bacterial toxins.

Going forward, the project needs many more samples to draw firm conclusions, but the early results have been described as ‘very promising’.

References

  1. 1) International Animal Health Journal http://animalhealthmedia.com/fish-vet-identifies-possible-cause-alabama-rot/ (accessed 30th January 2018)

Ten further confirmed Alabama Rot cases – 122 since 2012

Anderson Moores Vet Specialists advise on 16th January:

“Unfortunately, we have to confirm 10 further cases of cutaneous and renal glomerular vasculopathy (often termed CRGV or Alabama Rot). The cases were from Sacriston (County Durham), Guiseley (West Yorkshire), Bury and Bolton (Greater Manchester), Leek (Staffordshire), Petworth (West Sussex), Brighton (East Sussex), West Coker (Somerset), Bishop’s Tawton (Devon), and Presteigne in Powys.

This brings the total number of confirmed cases to 122 since 2012, with 37 cases in 2017 and the first two in 2018. We continue to advise owners to be vigilant and to seek advice from their local vet if their dog develops unexplained skin lesions/sores.

For help recognising some of the signs and to see a map of confirmed cases please visit www.vets4pets.com/stop-alabama-rot/” 

 

 

3 cases of Alabama Rot in West Midlands, Staffordshire and Cheshire

Anderson Moores advise 14th December 2017:

“Unfortunately, we have to confirm 3 further cases of cutaneous and renal glomerular vasculopathy (often termed CRGV or Alabama Rot). The cases were from Edgbaston (West Midlands), Cannock (Staffordshire) and Alsager (Cheshire)
This brings the total number of confirmed cases to 112 since 2012 with 29 in 2017. Most confirmed cases have been seen between October and April. We would continue to advise owners to be vigilant and to seek advice from their local vet if their dog develops unexplained skin lesions/sores.

For help recognising some of the signs and to see a map of confirmed cases please visit www.vets4pets.com/stop-alabama-rot/

Alabama Rot cases in Berkshire, Greater Manchester, Warwickshire, Staffordshire, Devon and Lancashire

Anderson Moores advise (30th November 2017):

“Unfortunately, we have to confirm another six cases of cutaneous and renal glomerular vasculopathy (often termed CRGV or Alabama Rot). The cases are from Frilsham (Berkshire), Little Lever, Bolton (Greater Manchester), Rugby (Warwickshire), Cannock (Staffordshire), Torquay (Devon) and Chorley (Lancashire).

This brings the total number of confirmed cases to 109 since 2012 with 26 in 2017. Most confirmed cases have been seen between October and April. We would continue to advise owners to be vigilant and to seek advice from their local vet if their dog develops unexplained skin lesions/sores.

For help recognising some of the signs and to see a map of confirmed cases please visit www.vets4pets.com/stop-alabama-rot/Source Anderson Moores facebook page.